Table 1. Annotation statistics for 194 human MS genes.
| Data category | Related entries | Annotated MS genes | Content/sources |
|---|---|---|---|
| General information | |||
| Human MS genes | 194 | 194 | Gene symbol, synonym, genomics position, gene type from Entrez gene database |
| Homologs | 1448 | 161 | Gene symbol and organism information |
| Literature | 550 | 194 | Curated literature evidence for MS genes |
| Function and regulation | |||
| Pathway | 1117 | 120 | KEGG and HumanCyc database, etc. |
| Disease | 1233 | 96 | NHGRI GWAS catalog and GAD databases, etc. |
| Transcription factor regulation | 2824 | 160 | Regulatory information initiated by human transcription factors |
| Post-translational modification | 703 | 102 | Experimentally verified PTMs from dbPTM |
| Expression and methylation | |||
| Cancer tissue | 194 | 133 | Expression in 184 cancer samples from BioGPS database |
| Normal tissue | 290 | 151 | Expression in 84 normal tissues from BioGPS database |
| Methylation | 2313 | 151 | Methylation in promoter regions from the DiseaseMeth database |
| Genomic variation and functional interaction | |||
| Mutations | 189,607 | 194 | Somatic mutational records from COSMIC database |
| Signaling interactions | 10,460 | 147 | Protein-protein interactions from PathwayCommons |
PTM: post-translational modification.