Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Intravital imaging of ER-mitochondrial Ca2+ transfer and its regulation by p53. Ca2+ is transferred to the ER by the SERCA pumps and is released by inositol 1,4,5-triphosphate (IP3)-gated channels (IP3R). p53 binds and activates SERCA pumps thus increasing the amount of Ca2+ storage into the ER. The Ca2+ released to the mitochondria after phototherapy leads to mitochondrial swelling with consequent apoptosis induction in p53+/+ tumors.
