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ONC201 induces caspase-dependent apoptosis in human lymphoma cell lines. (A) Sub-G1 DNA content analysis lymphoma cell lines treated with ONC201 at 0.625, 1.25, 2.5, 5 and 10 μM for 72 hours (n = 3). *P < 0.05; **P < 0.005. (B) Sub-G1 DNA content analysis of lymphoma cell lines in the presence or absence of the pan-caspase inhibitor zVAD-fmk (CI) and/or ONC201 for 72 hours.
