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. 2015 Jun 1;14(15):2422–2428. doi: 10.1080/15384101.2015.1054086

Figure 3.

Figure 3.

ONC201 induces the TRAIL pathway in human lymphoma cell lines. (A) Dose-response curve of BJAB cells to recombinant TRAIL or ONC201 at 72 hours post-treatment (n = 3). (B) Fold TRAIL expression of lymphoma cell lines at 60 hours post treatment with ONC201 (n = 3). (C) Correlation of surface TRAIL expression by flow cytometry with sub-G1 DNA content of Ramos, Karpas299, and UPN2 lymphoma cells treated with several doses of ONC201 (0.625, 1.25, 2.5, 5, and 10 μM, n = 3). The Pearson correlation coefficient “r” was 0.9499 with 95% confidence interval of 0.8526 to 0.9836 and a P value of <0.0001. (D) Reduction of cell death by co-incubation with RIK2, a TRAIL-sequestering antibody in Karpas299 cells with 72 hour treatment with ONC201 (n = 2).