Table 1.

Combination indices for ONC201 in combination with cytarabine

			Cytarabine(nM)
Karpas299			31.25	62.5	125	250	500	1000	2000
	ONC201 (uM)	0.3125	0.55	0.76	0.41	0.38	0.40	1.03	1.01
		0.625	0.54	0.64	0.46	0.50	0.46	1.12	1.01
		1.25	0.58	0.79	0.57	0.57	0.92	1.25	1.03
		2.5	0.70	0.64	0.66	0.72	0.83	1.10	1.13

Combination indices obtained for Karpas299 cells at 72H post combination treatment with increasing doses of ONC201 combined with increasing doses of cytarabine confirm synergistic cytotoxicity.