Table 3.

Risk of Cervical Intraepithelial Neoplasia Grade 3 or Greater (CIN-3+) After 3 or 5 Years of Follow-up, and Its Relationship With Oncogenic Human Papillomavirus Detection at Baseline in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Women With a Normal Baseline Pap Result^a

Characteristic	3 y HR (95% CI)	P Value	5 y HR (95% CI)	P Value
HPV status
OncHPV negative	Reference		Reference
OncHPV positive	5.3 (1.6–18.3)	.01	4.1 (1.3–12.8)	.02
CD4 count (HIV+)
HIV−	Reference		Reference
>500 cells/µL	1.3 (.2–9.4)	.8	1.0 (.2–4.5)	1.0
350–500 cells/µL	2.7 (.4–17.1)	.3	1.4 (.3–6.4)	.7
<350 cells/µL	3.7 (.6–23.1)	.2	1.8 (.4–7.8)	.5
Age at baseline (continuous)	0.9 (.9–1.0)	.1	1.0 (.9–1.0)	.2
Smoking
Never	Reference		Reference
Past	1.5 (.3–8.3)	.7	1.4 (.2–7.7)	.7
Current	1.1 (.3–4.2)	.9	1.7 (.5–5.8)	.4
Lifetime No. of male sexual partners
<5	Reference		Reference
5–9	1.1 (.2–5.4)	1.0	1.3 (.3–6.0)	.7
≥10	1.0 (.2–4.1)	1.0	1.1 (.3–4.4)	1.0

Abbreviations: CI, confidence interval; CIN, cervical intraepithelial neoplasia; HIV, human immunodeficiency virus; HPV, human papillomavirus; HR, hazard ratio; OncHPV; oncogenic human papillomavirus.

^a The number of covariates were a priori reduced from the model shown in Table 2 to decrease the degrees of freedom used in this model, given the smaller number of CIN-3+ than CIN-2+ events. In secondary data analysis, we observed similar results when incorporating nonparametric splines in the Cox model; that is, the average HRs after 3 or 5 years of follow-up, as measured using the area under the curve, were similar to those presented in the tables, and no statistically significant departures from proportionality were detected.