Table 1.
Summary of average OFT flow parameters for each developmental stage (n = 10). Data presented as means ± s.d. Statistical significance was determined with a two-sample Student's t-test, reporting two-tail p-values, for HH15 and HH18 values compared to HH13 values.
| HH13 | HH14 | HH15 | HH16 | HH17 | HH18 | |
|---|---|---|---|---|---|---|
| peak V (mm s−1) | 29.7 ± 2.2 | 27.8 ± 5.2 | 36.4 ± 5.5* | 39.7 ± 3.9 | 39.5 ± 4.7 | 39.3 ± 4.4* |
| max diameter (µm) | 397 ± 27 | 399 ± 21 | 375 ± 24 | 434 ± 41.9 | 499 ± 32 | 533 ± 55* |
| peak Q (mm3 s−1) | 1.8 ± 0.3 | 1.7 ± 0.3 | 2.0 ± 0.4 | 3.0 ± 0.6 | 3.9 ± 0.5 | 4.4 ± 0.9* |
| WSR (s−1) | 301 ± 36 | 280 ± 57 | 390 ± 68* | 369 ± 52 | 319 ± 49 | 299 ± 51 |
| cardiac cycle (ms) | 599 ± 59 | 554 ± 58 | 531 ± 39* | 462 ± 66 | 425 ± 33 | 419 ± 23* |
| SV (mm3 beat−1) | 0.22 ± 0.05 | 0.22 ± 0.04 | 0.25 ± 0.08 | 0.31 ± 0.07 | 0.38 ± 0.07 | 0.47 ± 0.11* |
| time of flow (%) | 41.9 ± 4.3 | 43.0 ± 6.9 | 41.4 ± 4.7 | 44.8 ± 6.1 | 47.0 ± 6.8 | 53.3 ± 8.4* |
*p-value < 0.05.