Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
MDA-MB-231 cells expressing 5M Smad3 show decreased cell invasion and CDK inhibition results in decreased MMP2 expression, decreased CDK-mediated phosphorylation of Smad3 at the T179 site, and restoration of proteins related to cell cycle arrest. (A) MDA-MB-231 cells were transfected with Vec, WT, or 5M Smad3 and invasion was assessed (B and C) MDA-MB-231 cells were treated with control DMSO (NT), CDK2i, or CDK4i and immunoblotting was performed to assess expression of study proteins.
