Figure 2.

Protein-protein interaction (PPI) networks and sub-networks formed by the altered genes. (A) The set of 253 unique differentially expressed genes were assessed for their interacting partners using the APID2NET plugin in Cytoscape. The resultant PPI network composed of 818 nodes and 2794 edges and was used to generate a layered network based on subcellular localization of the 818 proteins. Blue colored nodes are representative of proteins encoded by the differentially expressed genes while the gray ones are the interacting partners. (B) The PPI as in ‘A’ was used to identify sub-networks using the MCODE clustering algorithm and the top 3 node-dense networks are shown.