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. 2015 Oct 22;5:15501. doi: 10.1038/srep15501

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Phase I identified the expressed microRNAs (miRNAs) in pooled samples from acetaminophen toxicity (APAP-TOX) patients and acetaminophen overdose with no toxicity (APAP-no TOX) patients. In Phase II, expressed miRNAs were quantified in 27 APAP-TOX and 27 APAP-no TOX patients. For data processing, C_t values were calibrated for RNA recovery using the cel-miR-39-3p assay (which detects a synthetic miRNA spiked in to each sample during sample prep). In Phase III, random forest analysis was performed to develop the classifier model that was subsequently tested in the test set.