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. 2015 Oct 22;5:15501. doi: 10.1038/srep15501

Figure 3. miR-122-5p and miR-885-5p are released from human hepatocytes bound to the carrier protein Ago2.

Figure 3

Figure (A) Pearson correlation plot of circulating miR-885-5p and miR-122-5p across APAP-TOX and APAP-no TOX patients. Figure (B–D) represent the relative Ago2 fraction for miR-122-5p, miR-885-5p and miR-151a-5p respectively in APAP-TOX (N = 6) and APAP-no TOX (N = 6) patients. The Y axis represents the 2−ΔCt value obtained from the Ago2 pull-down minus the 2−ΔCt value obtained from the IgG pull-down from the same sample, both normalised by spiked-in synthetic miR-39. Statistically significant differences were determined by Mann Whitney Test. Figure (E) presents liver tissue from 2 patients whom underwent liver transplantation for severe acute liver failure due to acetaminophen overdose. Images from hematoxylin and eosin (H&E) and in situ hybridization for miR-122-5p and miR-885-5p are presented.