Table 1.
43-gene signature of differentially expressed genes in K562 cells ectopically expressing the C/EBPα-ER chimera. Upregulated (left column) and down-regulated (right column) selected genes are listed in alphabetical order
| Up-regulated genes | Downregulated genes |
|---|---|
| Acyl-CoA synthetase long-chain family member 1 | Ankyrin 1 |
| Annexin A1 | CD69 |
| C/EBPα | Cyclin D1 |
| C/EBPγ | Cyclin D2 |
| C/EBPδ | Cyclin-dependent kinase 6 (CDK 6) |
| C/EBPε | Cyclin-dependent kinase inhibitor 1C (CDKN1C) |
| CD64 | GATA2 |
| Chitinase-3-like protein 1 (CHI3L1) | Growth factor indipendent 1B (GFI-1 B) |
| CXCR4 | HOXC4 |
| Cyclin G2 | Interleukin-10α receptor (IL10α-r) |
| FUT4 | Interleukin-2 receptor γ (IL2-rG) |
| GCSF-receptor (GCSF-r) | JUN D |
| Interleukin-1 receptor (IL1-r) | Keratin 19 (K19) |
| Interleukin-4 receptor (IL4-r) | KIT |
| Interleukin-6 receptor (IL6-r) | Leptin receptor (LEP-r) |
| Matrxi metalloprotease 8 (MMP8) | Myc |
| Monocyte to macrophage differentiation-associated | Perforin 1 |
| Myeloperoxidase (MPO) | PIM2 |
| Neutrophil elastase (ELANE) | STAT5 A |
| Plasminogen activator, urokinase receptor (PLAUR) | T cell receptor β constant 1 |
| S100 calcium binding protein A8 | |
| Secretory leukocyte peptidase inhibitor (SLP1) | |
| TNFα-induced protein 6 (TNFAIP6) |