Caspase 8, 9, and 3 activity in HCC cells treated with TAX or TAX+TNF. Huh7 (left panels) and HepG2 (right panels) cells exposed to 0.1 μM TAX or TAX plus 15 ng/ml TNF for 2, 6, 12 and 24 hours. Caspase activities measured as indicated in Materials and Methods, data (means±SD ) expressed as nkatal×10–5/mg protein. Panels A and B, caspase 8; panels C and D, caspase 9; panels E and F, caspase 3. Significance of the differences vs controls: *P < 0.05, **P < 0.01 and ***P < 0.001; vs TAX: °P < 0.05, °°P < 0.01 and °°°P < 0.001.