Figure 1.

Notch signaling is decreased in human Barrett's esophagus. (A) Microarray analysis from 7 samples of Barrett's esophagus (BE) and their adjacent normal squamous esophagus for status of Notch signaling pathway, GEO accession Inhibition of Notch signaling in esophageal epithelial cells changes basal cell morphology in 3D cultures. #GSE13083. (B) Representative image of normal esophagus and Barrett's esophagus tissue from tissue microarray (TMA) stained for NOTCH1, ICN1 and HES1 (200X Magnification). (C) Average scoring for positive staining in the TMA and statistical analysis using Fisher's exact t-test.