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Inhibition of Notch signaling in esophageal epithelial cells decreases squamous K13+ cells and increases columnar K19+ cells in 3D organotypic culture. IHC staining of 3D organotypic cultures for squamous keratin K13 (A) and columnar keratin K19 (B) in MYC-CDX1 (left panel) and MYC-CDX1-dnMAML cultures (right panel) (200X and 400X Magnification).
