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Inhibition of Notch signaling in esophageal epithelial cells promotes a switch from the squamous lineage to a columnar lineage. qPCR of (A) squamous keratins K5, K13 and K14; (B) columnar keratins K8, K18, K19 and K20; (C) mucin genes MUC2, MUC3B, MUC5B and MUC17; (D) and differentiation genes DSC1 and DSC3 in MYC-CDX1 and MYC-CDX1-dnMAML cells. Graph represents mean ± SEM (n = 6). Student t-test was performed to determine significance, *P ≤ 0.05, **P ≤ 0.001.
