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Model. Inhibition of Notch signaling in conjunction with MYC and CDX1 expression promotes increased expression of columnar keratins and mucin genes as well as decreased expression of squamous keratins and other markers of differentiation. Inhibition of Notch also triggers changes in cell morphology in the basal layer. Inhibition of Notch signaling promotes KLF4 expression and the initiation of a transdifferentiation program toward a BE-like metaplasia.
