Figure 5.

Age-associated reduction of oocyte number in Sycp2l^−/− females. For each mouse, serial sections of one ovary were prepared and follicles containing an oocyte with visible nucleus counted in every fifth section. The sum of oocytes from all counted sections was considered the total number of oocytes per ovary. (A) Progressive loss of oocytes in Sycp2l^−/− females with age. Control genotypes included Sycp2l^+/− and wild-type. (B–F) Oocyte counts in ovaries from females at 10 dpp (B), 2 months (C), 8 months (D), 12 month (E) and 14 months of age (F). n, number of mice per genotype. P-values for Student's t-Test are shown. n.s., not significant.