Figure 5. MSC treatment reduces VLDL production.

(a) Body weight and cholesterol levels were monitored throughout the entire experiment. (b) Cholesterol distribution among plasma lipoprotein subclasses was determined by FPLC analysis after eight weeks WTD. For FPLC analysis serum of three mice was pooled. (c) Liver mRNA expression of lipoprotein lipase (LPL), (d) of SREBP-1c and SREBP-2, and (e) of acetyl-CoA carboxylase (Acc1), fatty acid synthase (FASN), stearoyl-CoA desaturase-1 (Scd1) is shown, relative to the expression of three housekeeping genes (SDHA, HPRT and Rpl27). All values are expressed as mean ± SEM and representative of all mice. *P < 0.05, **P < 0.01, ***P < 0.001.