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editorial

. 2015 Aug 17;14(17):2723–2724. doi: 10.1080/15384101.2015.1063356

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Figure 1. — Two isoforms of hCAP-H2, the regulatory subunit of condensin II. The SMC2 and SMC4 subunits are members of the structural maintenance of chromosomes (SMC) family of chromosomal ATPases and are shared with condensin I. hCAP-D3 (D3) and hCAP-G2 (G2) are subunits unique to condensin II. uORF facilitates the re-initiation of translation from a downstream in-frame AUG (ΔN). The full-length (FL) isoform is mainly expressed at mitosis, whereas the ΔN appears to be expressed both in mitosis and interphase and is upregulated in both quiescence and senescence conditions. When overexpressed, both isoforms induce SAHF in IMR90 cells, where they are localized in the area surrounding SAHF. The mRNA diagram is not to scale.