Figure 7.

(A) Link between CD151 and receptor tyrosine kinase Ron in mammary epithelial cells. (A) Expression of Ron, Slit2, Robo1 and related signaling molecules in mammary glands. Blotting was conducted with tissues collected from CD151 WT (+/+) and KO (−/−) mice (n =3). (B) Altered signaling of Ron kinase. Human breast carcinoma cell lines (HCC-1937 and T47D), with and without CD151 ablation, were starved and subsequently stimulated with 30 ng/mL MSP, a ligand for Ron, followed by lysing in RIPA buffer and blotting with indicated signaling antibodies. (C) A working model of CD151 function during pubertal development of mammary glands.