Table 1.

Phenotypes of D. discoideum mutants with defects in components of the Hippo pathway

Strain	growth	cell size	cytokinesis	centrosome	development	motility	phagocytosis	phototaxis	polarity	adhesion
LATS/NdrC22	normal	increased	multinucleated	extra centrosomes	nt	nt	nt	nt		nt
NdrA 40	impaired on Ka			nt	normal	nt	defective	normal		nt
SvkA (Hrk-Svk) 20	delayed on K.a.		multinucleated	nt	delayed, aberrant fbs			defective	affected	nt
Krs1(KrsA)29	normal			nt	normal; but no streams formed when submerged	reduced	normal (yeast)	normal	less polarized	nt
KrsB 21	abnormal plaques on K.a.			nt	delayed; prolonged streaming; abnormal and smaller fbs	reduced		defective	affected	reduced
CEP161 D1	faster in shaking; slower on K.a.	like wild type (WT)	like WT	increased numbers	larger fbs	reduced	defective	defective		reduced
CEP161 D2	faster in shaking; slower on K.a.	like wild type	like WT	Increased numbers	larger fbs	reduced	defective	defective		reduced
CEP161 D3	faster on K.a.	smaller	like WT	normal	delayed streaming; overall delay; larger structures	reduced		defective	affected	reduced
CEP161 FL	normal	increased	like WT	normal	slightly larger fbs	normal	defective	normal		?

Nt, not tested; WT, wild type, K.a., Klebsiella aerogenes, fb, fruiting body.