Figure 4.

PreSTIGE prediction of enhancers overlapping activating ncRNAs. A tissue-specific enhancer is predicted in K562 cells that overlap previously identified activating ncRNAs ncRNA-a3 and ncRNA-a4 shown to target TAL1 and CMPK1, respectively. Predicted enhancers are shown as black boxes (K562 enhancers). The ENCODE annotated transcripts are shown for discontinuous regions of the locus. See scale bar and coordinates. K562 PolII ChIA-PET data are from Li et al.²² as deposited in the UCSC genome browser, and show interacting regions as experimentally determined. Additionally, H3K4me1 and RNA sequencing data from ENCODE are shown for representative cell lines.