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. 2015 Jun 1;14(14):2251–2264. doi: 10.1080/15384101.2015.1056421

Figure 2.

Figure 2.

A sequence presenting uninterrupted replication. Replication starts from multiple sites (A) with the most active origins (green) firing earlier and the less active (less efficient) ones being delayed (blue) or dormant (gray). When an active origin starts replication, a double MCM2–7 complex divides and single MCM2–7 helicases move forward in both directions, replicating the DNA strand (B, indicated by arrows). Less efficient (blue) or dormant (gray) origins that fail to activate disassemble when the replication forks reach them and are replicated passively (C). When replication forks reach the end of a chromosome or another fork comes from the other side, they also get dismantle – the final ‘product’ of this process is replicated DNA (D).