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. 2014 Oct 29;13(22):3541–3550. doi: 10.4161/15384101.2014.960729

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Figure 6. — Depletion of ATR in ATM-deficient HME-CC cells sensitizes cells to DNA-damaging drugs (A) Bleomycin and (B) Etoposide. Cells were induced for ATR shRNA expression by doxycycline for 2 d prior to drug treatment and cell viability was evaluated by CellTiter-Blue assay at 48 h post drug treatment. All presented values were calculated by dividing the average fluorescent signal in treated cells with that in its own time-matched untreated counterpart. *means cell viability is significantly different from wild-type (LacZ-NS) (P < 0.05); **means change in cell viability due to ATM/ATR double depletion is significantly greater than the sum of that due to ATM or ATR depletion alone (P < 0.05).