Figure 1.

Neurofibromin and its yeast homologs, Ira1 and Ira2. (A) Schematic diagram of the full-length neurofibromin, Ira1, and Ira2. The cysteine and serine-rich domain/Ras-GTPase activating protein domain (CSRD/RasGAP) and C-terminal domain (CTD) of neurofibromin are conserved in its yeast homologs Ira1 and Ira2. CSRD/RasGAP is shown in light gray, and the neurofibromin CTD and Ira 1/2 neurofibromin CTD-homologous domain (CHD) in dark gray. (B) Alignment of the CTD and CHD amino acid sequences using Vector NTI software (Invitrogen). Identical amino acids are shown in black, conserved amino acids in gray.