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. 2015 Jun 3;14(12):1893–1907. doi: 10.1080/15384101.2015.1041686

Figure 3.

Figure 3.

Effects of PGRN on ER stress and insulin signaling in liver, adipose tissue and skeletal muscle. All analyses compared age- and sex-matched mice injected daily with saline solution or PGRN for 21 d. For insulin signaling, they were injected with 2 IU/kg of insulin (Ins). The relative quantity of proteins was analyzed using the Image J software. (A–C) Phosphorylation of IRS-1 tyrosine and Akt Ser-473 in liver, adipose tissue and skeletal muscle. (D–F) The phosphorylation of PERK and eIF2α in the liver, adipose tissue and skeletal muscle of mice co-treated with insulin and PGRN. The data expressed as means ± SEM in each bar graph. *P < 0.05, **P < 0.01 (vs. vehicle). #P < 0.05 (vs. Ins).