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. 2015 Jan 21;14(7):973–979. doi: 10.1080/15384101.2015.1006970

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Figure 3. — PTEN reactivation promotes apoptosis in BCR-ABL positive cells. (A) Parental and BCR-ABL-NIH3T3 were transfected with the indicated GFP-tagged-PTEN vectors. After 48 hours, PTEN phosphatase assay was performed in immunoprecipitated GFP-PTEN. *P <0.05; **P<0.01. (B) Western immunoblot of BCR-ABL-NIH3T3 cells transfected with the indicated GFP-PTEN mutants. Phospho-PTEN: PTEN-S380/T382/T383. (C) Apoptosis was assessed in NIH3T3 cells treated with 60 μM TBB and 1 μM Imatinib for 10 hours. Data are mean and d.s. of two independent experiments. After short incubation period with inhibitors, in BCR-ABL-NIH3T3 cells, solvent vs. TBB and solvent vs. TBB/imatinib differences are significant with *P<0.05.