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. 2015 Apr 18;12(7):728–741. doi: 10.1080/15476286.2015.1040978

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Benjamin P Towler, Christopher I Jones, Sandra C Viegas, Patricia Apura, Joseph A Waldron, Sarah K Smalley, Cecilia M Arraiano, and Sarah F Newbury

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Dis3 knockdown in the wing pouch of the wing imaginal discs results in small wing discs and extensive apoptosis. (A and B) Dis3 knockdown (nub-GAL4/+ ; UAS-Dis3^RNAi/+) late L3 wing imaginal discs (B) are smaller than parental control (Dis3^WT is ;; UAS-Dis3^RNAi) wing imaginal discs (A) (scale bar=50μm). (C) Quantitation of nub-GAL4 driven Dis3 knockdown wing imaginal discs shows that they are 23% smaller than parental control discs ('Dis3^WT' includes parental genotypes ; nub-GAL4 ; and ;;UAS-Dis3^RNAi). (n ≥ 21, P < 0.0001, error bars represent standard error). (D and E) Knockdown of Dis3 in the wing pouch results in apoptosis specifically localized within the wing pouch region (E) while parental control discs show very little apoptotic activity (D). (n ≥ 26, scale bar = 50 μm).