Table 2.
Summary of missexpressed miRNAs in Dis3 knockdown wing imaginal discs
| miRNA | Fold changeSeq/qRT-PCR | Conservation | Known function in Drosophila | Validated targets in Drosophila | Clustering (same transcriptional unit) | References |
|---|---|---|---|---|---|---|
| miR-987–5p | +49.5/+16.8 | Dm | Unknown | None identified | No | |
| miR-277–3p | +10.4/+3.7 | Dm | Controls valine leucine and isoleucine degradation | None identified | miR-34 | 48,49 |
| miR-252–5p | +4.2/+2.1 | Sp, Dm, Ce, | Misregulated in stress and dystrophy | None identified | No | 50 |
| miR-34–5p | +2.7/+1.4 | Hs, Sp, Dm, Ce | Negative regulation of neuronal cell death | Su(z)12, Eip74EF | miR-277 | 51,52 |
| miR-317–5p | +2.4/2.1 | D | Brain morphogenesis | None identified | No | 53 |
| miR-9b-3p | −2.0/−1.5 | Hs, Sp, Dm, Ce, | Unknown | None identified | miR-9c, miR-306 and miR-79. | |
| miR-982–5p | −2.2/−4.4 | Dm | Unknown | None identified | No |
Hs – Homo sapiens, Sp – Strongylocentrotus purpuratus, Dm – Drosophila melanogaster, Ce – Caenorhabditis elegans. *miR-317 is located in close proximity to miR-34 and miR-277. **miR-982 is located in close proximity to miR-984, miR-303, miR-983–1 and miR-983–2. Conservation taken from miRBase release 19.