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Model of nuclear shape determination. Myosin XI-i is anchored to the SUN-WIP NE bridges by WIT2. This SUN-WIP-WIT2-myosin XI-i complex transfers cytoplasmic forces to the NE. In the nucleoplasm, CRWN1 acts independently on nuclear shape determination by forming lamina-like structures. Other nucleoplasmic proteins that affect nuclear shape—CRWN4, KAKU4, and NUP136—and the CRWN1-SUN interaction of unknown function are not drawn.
