. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Pediatr Obes. 2015 Apr 20;11(2):95–101. doi: 10.1111/ijpo.12026

Table 3.

Interaction effects¹ for nominally significant G-G interactions on BMI Z-score in Add Health, CHOP, and meta-analysis.

SNP1/SNP2	Add Health (N=5075)		CHOP (N=3814)		Meta-analysis (N= 8889)
SNP1/SNP2	Beta (SE)	p	Beta (SE)	p	Beta (SE)	p	Direction	Het ISq	HetPVal
LMX1B/MTIF3	−0.18 (0.04)	2.88E-05	1.49E-03 (0.06)	0.979	−0.12 (0.03)	2.82E-04	−+	85.8	0.008
TNNI3K/LRP1B	−0.12 (0.04)	0.005	−0.04 (0.05)	0.459	−0.09 (0.03)	0.005	− −	42.6	0.187
SLC39A8/FTO	0.15 (0.06)	0.007	−0.05 (0.06)	0.417	0.05 (0.04)	0.257	+−	82.2	0.018
POMC/LMX1B	−0.10 (0.04)	0.008	−0.07 (0.04)	0.119	−0.09 (0.03)	0.004	− −	0	0.617
LZTR2/KCTD15	0.10 (0.04)	0.009	0.04 (0.05)	0.422	0.07 (0.03)	0.015	++	0	0.325
CADM2/NRXN3	−0.11 (0.05)	0.018	0.01 (0.05)	0.905	−0.06 (0.04)	0.123	−+	59.7	0.115
LRP1B/NRXN3	−0.12 (0.05)	0.019	−0.13 (0.06)	0.037	−0.13 (0.04)	1.48E-03	− −	0	0.866
TFAP2B/MAP2K5	0.11 (0.05)	0.020	0.02 (0.05)	0.740	0.06 (0.04)	0.072	++	41.5	0.191
ETV5/LRRN6C	0.09 (0.04)	0.027	−0.04 (0.05)	0.345	0.03 (0.03)	0.271	+−	78.9	0.029
FANCL/MTCH2	−0.07 (0.03)	0.028	0.01 (0.04)	0.844	−0.04 (0.02)	0.087	−+	60.8	0.110
PRKD1/FTO	−0.14 (0.07)	0.029	−0.27 (0.08)	0.001	−0.19 (0.05)	2.81E-04	− −	27.5	0.240
MTCH2/MC4R	0.08 (0.04)	0.030	3.05E-03 (0.04)	0.941	0.04 (0.03)	0.136	++	44.1	0.181
LZTR2/MAP2K5	0.09 (0.04)	0.030	−0.04 (0.05)	0.484	0.04 (0.03)	0.172	+−	72.9	0.055
TNNI3K/TFAP2B	0.08 (0.04)	0.031	0.07 (0.04)	0.087	0.08 (0.03)	0.009	++	0	0.906
GNPDA2/KCTD15	−0.07 (0.03)	0.031	−0.01 (0.04)	0.822	−0.05 (0.02)	0.051	− −	40.4	0.195
NEGR1/KCTD15	−0.07 (0.03)	0.032	0.02 (0.04)	0.671	−0.04 (0.02)	0.124	−+	69.3	0.071
NEGR1/POMC	0.07 (0.03)	0.033	0.01 (0.04)	0.776	0.04 (0.02)	0.050	++	40.4	0.195
FANCL/MTIF3	−0.08 (0.04)	0.035	0.07 (0.05)	0.134	−0.02 (0.03)	0.589	−+	83.2	0.015
NUDT3/MAP2K5	0.09 (0.04)	0.036	3.59E-04 (0.05)	0.994	0.05 (0.03)	0.081	++	50.3	0.156
LZTR2/MC4R	0.09 (0.04)	0.039	−0.02 (0.05)	0.683	0.05 (0.03)	0.120	+−	64.5	0.093
GNPDA2/NRXN3	−0.08 (0.04)	0.039	0.02 (0.04)	0.734	−0.04 (0.03)	0.210	−+	60.7	0.111
NCR3_BAT2/QPCTL	0.08 (0.04)	0.040	0.03 (0.04)	0.430	0.06 (0.03)	0.046	++	0	0.429
ETV5/NUDT3	−0.09 (0.05)	0.041	0.10 (0.05)	0.047	2.80E-03 (0.04)	0.938	−+	86	0.007
NUDT3/KCTD15	−0.08 (0.04)	0.045	−0.02 (0.05)	0.681	−0.05 (0.03)	0.074	− −	0	0.322
FANCL/ETV5	0.08 (0.04)	0.048	0.01 (0.05)	0.908	0.05 (0.03)	0.110	++	31.6	0.227
POMC/GNPDA2	−0.06 (0.03)	0.048	0.04 (0.04)	0.302	−0.02 (0.02)	0.407	−+	77.2	0.036
CADM2/MC4R	−0.09 (0.05)	0.049	9.85E-04 (0.05)	0.984	−0.04 (0.04)	0.209	−+	39.8	0.197
MTCH2/ZC3H4	−0.06 (0.03)	0.050	−0.04 (0.04)	0.332	−0.05 (0.02)	0.030	− −	0	0.647

Footnote: Mixed effects model, $BMI = β + β SNP 1 \times SNP 2 + β SNP 1 + β SNP 2 + β age + β sex + f + s + ∊$ , Betas shown in table refer to βSNP1×SNP2.