Table 2.

Association of Baseline Fitness With the Development of Dyslipidemias Over 25 Years

	Low HDL-C (<40 mg/dL)	High TG (≥200 mg/dL)	High LDL-C (≥160 mg/dL)
Baseline treadmill test duration (per 2.0 min increment)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Total Population	N=3,910 (1,081 cases)	N=4,359 (699 cases)	N=4,507 (869 cases)
Model 1	0.91 (0.86–0.97)	0.84 (0.77–0.90)	0.86 (0.80–0.93)
Model 2	0.98 (0.92–1.04)	0.88 (0.81–0.95)	0.92 (0.85–0.99)
Men	N=1,678 (693 cases)	N=1,957 (451 cases)	N=1,896 (459 cases)
Model 1	0.91 (0.84–0.97)	0.85 (0.77–0.93)	0.89 (0.81–0.98)
Model 2	0.96 (0.89–1.04)	0.88 (0.81–0.98)	0.94 (0.85–1.04)
Women	N=2,222 (386 cases)	N=2,387 (246 cases)	N=2,436 (408 cases)
Model 1	0.90 (0.80–1.02)	0.80 (0.69–0.93)	0.84 (0.74–0.94)
Model 2	0.98 (0.86–1.11)	0.82 (0.71–0.96)	0.90 (0.80–1.02)
Blacks	N=1,992 (517 cases)	N=2,180 (254 cases)	N=2,281 (400 cases)
Model 1	0.95 (0.87–1.04)	0.88 (0.77–1.002)	0.90 (0.80–1.007)
Model 2	0.99 (0.90–1.09)	0.95 (0.83–1.08)	0.93 (0.83–1.05)
Whites	N=1,918 (564 cases)	N=2,179 (445 cases)	N=2,226 (469 cases)
Model 1	0.91 (0.84–0.99)	0.83 (0.75–0.91)	0.85 (0.77–0.94)
Model 2	0.98 (0.90–1.07)	0.86 (0.77–0.95)	0.92 (0.83–1.02)

Values are presented as HR (95% CI) per 2.0 min increment in baseline treadmill time. Model 1 adjusted for age, center, baseline BMI, lipid meds, smoking, education, alcohol consumption, and race and/or sex (when appropriate). Model 2 adjusted for Model 1 variables plus baseline trait value (e.g., baseline HDL-C). Both models in women adjusted for menopausal status. Number at risk and number of incident cases is given for each group for each dyslipidemic trait. Boldface indicates statistical significance (p<0.05).