Table 2.
Association of Baseline Fitness With the Development of Dyslipidemias Over 25 Years
| Low HDL-C (<40 mg/dL) |
High TG (≥200 mg/dL) |
High LDL-C (≥160 mg/dL) |
|
|---|---|---|---|
| Baseline treadmill test duration (per 2.0 min increment) |
HR (95% CI) | HR (95% CI) | HR (95% CI) |
| Total Population | N=3,910 (1,081 cases) | N=4,359 (699 cases) | N=4,507 (869 cases) |
| Model 1 | 0.91 (0.86–0.97) | 0.84 (0.77–0.90) | 0.86 (0.80–0.93) |
| Model 2 | 0.98 (0.92–1.04) | 0.88 (0.81–0.95) | 0.92 (0.85–0.99) |
| Men | N=1,678 (693 cases) | N=1,957 (451 cases) | N=1,896 (459 cases) |
| Model 1 | 0.91 (0.84–0.97) | 0.85 (0.77–0.93) | 0.89 (0.81–0.98) |
| Model 2 | 0.96 (0.89–1.04) | 0.88 (0.81–0.98) | 0.94 (0.85–1.04) |
| Women | N=2,222 (386 cases) | N=2,387 (246 cases) | N=2,436 (408 cases) |
| Model 1 | 0.90 (0.80–1.02) | 0.80 (0.69–0.93) | 0.84 (0.74–0.94) |
| Model 2 | 0.98 (0.86–1.11) | 0.82 (0.71–0.96) | 0.90 (0.80–1.02) |
| Blacks | N=1,992 (517 cases) | N=2,180 (254 cases) | N=2,281 (400 cases) |
| Model 1 | 0.95 (0.87–1.04) | 0.88 (0.77–1.002) | 0.90 (0.80–1.007) |
| Model 2 | 0.99 (0.90–1.09) | 0.95 (0.83–1.08) | 0.93 (0.83–1.05) |
| Whites | N=1,918 (564 cases) | N=2,179 (445 cases) | N=2,226 (469 cases) |
| Model 1 | 0.91 (0.84–0.99) | 0.83 (0.75–0.91) | 0.85 (0.77–0.94) |
| Model 2 | 0.98 (0.90–1.07) | 0.86 (0.77–0.95) | 0.92 (0.83–1.02) |
Values are presented as HR (95% CI) per 2.0 min increment in baseline treadmill time. Model 1 adjusted for age, center, baseline BMI, lipid meds, smoking, education, alcohol consumption, and race and/or sex (when appropriate). Model 2 adjusted for Model 1 variables plus baseline trait value (e.g., baseline HDL-C). Both models in women adjusted for menopausal status. Number at risk and number of incident cases is given for each group for each dyslipidemic trait. Boldface indicates statistical significance (p<0.05).