. 2015 Sep 15;6(11):1130–1139. doi: 10.7150/jca.12719

Table 4.

Univariate and multivariate analyses for PFS and OS in PKM2 high expression cohort

Variables	PFS			OS
Variables	HR	95%CI	P value	HR	95%CI		P value
Univariate analysis
Age(<50 vs.≥50) (years)	0.611	0.317-1.179	0.142	0.685		0.335-1.398	0.298
Tumor size (≤ 2 vs. >2)(cm)	2.563	1.128-5.822	0.025^*	3.018		1.161-7.840	0.023^*
Lymph node (N0 vs. N1 vs. N2+N3)	1.701	1.195-2.420	0.003^*	1.721		1.169-2.534	0.006^*
Histological grade (Ⅰvs. Ⅱvs. Ⅲ)	1.066	0.578-1.965	0.837	1.068		0.561-2.033	0.841
*Clinical treatments*
Chemotherapy (non-EPI/5-Fu vs. EPI-based + EPI plus 5-Fu)	0.348	0.180-0.674	0.002^*	0.302	0.149-0.614		0.001^*
Chemotherapy (non-EPI/5-Fu vs. EPI-based + EPI plus 5-Fu)	0.348	0.180-0.674	0.002^*	0.302	0.149-0.614		0.001^*
Endocrine therapy (no vs. yes)	0.938	0.596-2.532	0.576	1.137	0.510-2.531		0.754
Bio-therapy (no vs. yes)	0.607	0.321-1.149	0.125	0.534	0.266-1.075		0.079
Radio-therapy (no vs. yes)	1.384	0.733-2.614	0.317	1.482	0.740-2.969		0.267
Multivariate analysis
Tumor size (≤ 2 vs. >2)(cm)	1.659	0.695-3.960	0.254	1.848	0.668-5.110		0.237
Lymph node (N0 vs. N1 vs. N2+N3)	1.577	1.087-2.288	0.016^*	1.555	1.034-2.338		0.034^*
Chemotherapy (non-EPI/5-Fu vs. EPI-based + EPI plus 5-Fu)	0.355	0.181-0.698	0.003^*	0.322	0.157-0.663		0.002^*

*indicates P<0.05