Figure 4.

Major differences in the gut microbiota profile between the least developed, developing and dev;loped representative countries.The transformation of the gut microbiota in children to that of adult gut microbiota happens in the span of first 3 years of life. The functionality of the microbiota in children focused on enzymes of folic acid biosynthesis while in adults, the focus was on biosynthesis of biotin, cobalmin and thiamine and breakdown of folic acid. Malawian and Amerindian flora were very similar to that of herbivorous mammals. Enzymes for anabolism of metabolites like riboflavin synthesis, glutamate synthesis and amylase were highly represented. Gut microbiota of USA population is similar to carnivorous mammals, (enzymes for catabolism of metabolites like enzymes for degradation of amino acids, glycan degradation were highly represented).