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. 2015 Mar 11;12(4):457–477. doi: 10.1080/15476286.2015.1014288

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Figure 10. — Probable mechanism of cross-talk between p53 and NFκB p65/RelA (p65) in regulating miRNA expression Cross-talk between p53 and p65 in regulating miRNA expression where p53 represses p65 transactivation by (A) Exclusion Model in which elevated p63 displaces p65 from overlapping or nearby DNA binding sites; (B) Competition Model in which elevated p53 competes with p65 for p300/CBP binding; (C) Cis-repression Model in which p53 binds with DNA and recruits HDAC and suppresses expression of genes.