Table 2.
Patients’ data and important findings during the early course at the intensive care unit
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
| Time of increase of liver | |||||
| function tests > 2× ULN (d) | |||||
| GGT | 101 | 6 | 5 | 4 | 11 |
| AP | 18 | 18 | 9 | 12 | 15 |
| Bilirubin | 36 | 62 | 10 | 8 | 13 |
| AST | 18 | 52 | 9 | 12 | 16 |
| ALT | 18 | 23 | 9 | 7 | 19 |
| Mechanical ventilation (d) | 36; | 13; | 25; | 16; | 62; |
| PEEPmax. 6 mmHg; | PEEPmax. 10 mmHg; | PEEPmax. 8 mmHg; | PEEPmax. 15 mmHg; | PEEPmax. 20 mmHg; | |
| FiO2 not documented | FiO2max. 0.6 | FiO2max. 0.6 | FiO2max. 0.7 | FiO2max. 0.6 | |
| Severe hypotension | d 1 (2 h) | d 1 (45 min) | d 2 (30 min) and | d 1 (30 min) | None |
| (systolic blood pressure | d 3 (60 min) | ||||
| < 70 mm Hg)3 | |||||
| Vasopressor therapy | Dobutamine d 1-8 | None | Norepinephrine d 3-5 | Norepinephrine d 2-4 | None |
| dopamine d 1-18 | and d 9-17 | ||||
| norepinephrine d 1-7 | |||||
| Minimum hemoglobin3 | 7.3 g/dL (d 3) | 2.4 g/dL (d 1) | 7.2 g/dL (d 3) | 8.6 g/dL (d 1) | 7.9 g/dL (d 4) |
| Transfusions (RBC units)3 | 30 | 34 | 10 | 10 | 24 |
| Fever (> 38.0 ) | d 7-16 | d 6-13 | d 2-25 | d 5-17 | d 2- >20 |
| Antibiotics3 | Cefotaxim, imipenem, | None | Piperacillin/sulbactam | None | Piperacillin/tazobactam, |
| sulbactam, mezlocillin | ciprofloxacin, meropenem, | ||||
| levofloxacin, fluconazol |
ALT: alanine aminotransferase; AP: alkaline phosphatase; AST: aspartate aminotransferase; FiO2max.: maximum fraction of inspired oxygen; GGT: gamma glutamyl transferase; PEEPmax.: maximum positive end-exspiratory pressure; ULN: upper limit of normal 1No control of liver function tests between d 4 and 10; 2A bilirubin value 2× ULN was noted only once at d 6;
3
Until increase of GGT ≥ 2× ULN.