Table 4.
Associations between Incident Wrist Fracture and Subsequent Fracture
| Wrist Fracture | ||||
|---|---|---|---|---|
|
| ||||
| No | Yes | |||
|
| ||||
| Total N | Event | HR (95% CI) | ||
|
| ||||
| Any non-wrist fracture | ||||
| Crude | 160,930 | 33,979 | 1 (ref) | 1.54 (1.46–1.62) |
| Model 1§§ | 159,118 | 33,596 | 1 (ref) | 1.40 (1.33–1.48) |
| Model 2*** | 139,790 | 29,540 | 1 (ref) | 1.40 (1.32–1.49) |
| Model 3††† | 136,017 | 28,790 | 1 (ref) | 1.37 (1.29–1.46) |
|
| ||||
| Spine Fracture | ||||
| Crude | 160,930 | 5,373 | 1 (ref) | 1.75 (1.57–1.96) |
| Model 1 | 159,118 | 5,301 | 1 (ref) | 1.48 (1.32–1.66) |
| Model 2 | 139,790 | 4,658 | 1 (ref) | 1.51 (1.34–1.70) |
| Model 3 | 136,017 | 4,544 | 1 (ref) | 1.46 (1.29–1.65) |
|
| ||||
| Humerus Fracture | ||||
| Crude | 160,930 | 4,361 | 1 (ref) | 1.99 (1.76–2.26) |
| Model 1 | 159,118 | 4,309 | 1 (ref) | 1.78 (1.57–2.02) |
| Model 2 | 139,790 | 3,793 | 1 (ref) | 1.72 (1.50–1.96) |
| Model 3 | 136,017 | 3,676 | 1 (ref) | 1.67 (1.46–1.92) |
|
| ||||
| Upper extremity (non-wrist) fracture‡‡‡ | ||||
| Crude | 160,930 | 7,312 | 1 (ref) | 2.06 (1.87–2.27) |
| Model 1 | 159,118 | 7,228 | 1 (ref) | 1.88 (1.70–2.07) |
| Model 2 | 139,790 | 6,360 | 1 (ref) | 1.85 (1.67–2.06) |
| Model 3 | 136,017 | 6,184 | 1 (ref) | 1.80 (1.62–2.01) |
|
| ||||
| Lower extremity Fracture§§§ | ||||
| Crude | 160,930 | 15,034 | 1 (ref) | 1.41 (1.30–1.53) |
| Model 1 | 159,118 | 14,867 | 1 (ref) | 1.36 (1.26–1.48) |
| Model 2 | 139,790 | 13,051 | 1 (ref) | 1.35 (1.24–1.48) |
| Model 3 | 136,017 | 12,718 | 1 (ref) | 1.30 (1.19–1.43) |
|
| ||||
| Hip fracture | ||||
| Crude | 160,930 | 3,836 | 1 (ref) | 1.97 (1.73–2.24) |
| Model 1 | 159,118 | 3,801 | 1 (ref) | 1.50 (1.32–1.71) |
| Model 2 | 139,790 | 3,291 | 1 (ref) | 1.51 (1.31–1.74) |
| Model 3 | 136,017 | 3,186 | 1 (ref) | 1.48 (1.28–1.71) |
Model 1 adjusted for age, race, and BMI
Model 2 is adjusted for covariates in Model 1 plus education, income, cigarette smoking status, pack-years of cigarette smoking, total metabolic equivalent of task hours/week, dietary calcium intake, calcium supplement intake, dietary vitamin D intake, vitamin D supplement intake, WHI-Hormone Therapy Trials treatment assignment, and WHI Dietary Modification Trial treatment assignment
Model 3 is adjusted for covariates in Model 2 plus number of falls, alcohol intake, history of cancer, and physical function score
Includes elbow, hand, upper arm/humerus, and shoulder fractures, excludes finger fractures
Includes foot, knee/patella, upper leg, and lower leg/ankle fractures, excludes hip fractures