Table 5.

African American participants from ALIVE, UHS and WIHS with chronic or cleared HCV infection, genotype proportions for IFNL4-ΔG/TT (rs368234815) and IFNL3 rs4803217 variants, and corresponding Mantel-Haenszel (M-H) odds ratios, 95% confidence intervals (95% CI) and p-values for each association.

	Variant	IFNL4-ΔG/TT			rs4803217
	Genotype	ΔG/ΔG	ΔG/TT	TT/TT	T/T	T/G	G/G
ALIVE	Chronic (%) [N= 534]	43.3 [231]	45.9 [245]	10.9 [58]	40.6 [217]	44.8 [239]	14.6 [78]
	Cleared (%) [N= 59]	23.7 [14]	39.0 [23]	37.3 [22]	23.7 [14]	30.5 [18]	45.8 [27]
	Odds ratio	Ref.	1.55	6.26	Ref.	1.17	5.37
	95% CI	-	0.78–3.08	3.02–12.98	-	0.57–2.45	2.68–10.76
	p-value		0.21	8.3×10−7		0.67	2.2×10−6
UHS	Chronic (%) [N=276]	36.6 [101]	50.0 [138]	13.4 [37]	32.2 [89]	52.5 [145]	15.2 [42]
	Cleared (%) [N=87]	24.1 [21]	47.1 [41]	28.7 [25]	25.3 [22]	47.1 [41]	27.6 [24]
	Odds ratio	Ref.	1.43	3.25	Ref.	1.14	2.31
	95% CI		0.80–2.57	1.63–6.49		0.64–2.05	1.17–4.59
	p-value		0.23	8.4×10−4		0.65	0.02
WIHS	Chronic (%) [N=437]	41.2 [180]	46.5 [203]	12.4 [54]	36.2 [158]	46.5 [203]	17.4 [76]
	Cleared (%) [N=82]	31.7 [26]	32.9 [27]	35.4 [29]	26.8 [22]	37.8 [31]	35.4 [29]
	Odds ratio	Ref.	0.92	3.72	Ref.	1.10	2.74
	95% CI	-	0.52–1.65	2.02–6.85	-	0.61–1.97	1.48–5.08
	p-value		0.78	2.0×10−5		0.76	0.001
TOTAL	Chronic (%) [N=1,247]
	Cleared (%) [N=228]
	M-H Odds ratio	Ref.	1.25	4.14	Ref.	1.15	3.22
	95% CI		0.88–1.77	2.81–6.11		0.80–1.64	2.20–4.72
	p-value		0.21	7.2×10−13		0.45	2.0×10−9