Table 1.
Representative cellular and viral cap methyltransferases with experimentally characterized RNA cap methyltransferase activities. The enzymes, for which crystal structures were determined, are shown in bold.
| Methylation position | base |
2′-O-ribose |
other |
||||
|---|---|---|---|---|---|---|---|
| Species | cap0 | TMG | cap1 | cap2 | cap3/cap4 | ɣ-phosphate | |
| cellular enzymes | Homo sapiens | RNMT7,26 | TGS169,70 | CMTr138 | CMTr246 | BCDIN382 | |
| Saccharomyces cerevisiae | Abd12 | Tgs164 | |||||
| Encephalitozoon cuniculi | Ecm125 | ||||||
| Giardia lamblia | Tgs165, Tgs268 | ||||||
| Trypanosoma brucei | TbCmt127, TbCgm183 | TbTgs184 | TbMTr141,42 | TbMTr227 | TbMTr347 | ||
| viral enzymes | Vaccinia virus | D1/D1228,29 | VP3985 | ||||
| Flavivirus | NS560 | NS560 | |||||
| Vesicular stomatitis virus | L protein52 | L protein52 | |||||
| Reovirus | lambda 249 | lambda 249 | |||||
| Bluetongue virus | VP451 | VP451 | |||||
| SARS-Coronavirus | nsp1434 | nsp16/nsp1043 | |||||