Table 1.

DAVID analysis of up-regulated or down-regulated genes in miR-21 knockout HeLa cells

Up Cluster Representative Term	Enrichment Score	Representative Genes
Cell adhesion	8.16	PCDHA6, PCDHA7, PCDHA8, PCDHA2, TNFRSF12A, PCDHA3, TNC, PCDHA4, IGFBP7, PCDHA5, ITGA11, ITGB5, NEDD9, CDH2, PCDHA1, PCDHAC2, PCDHAC1, CD97, CTGF, TGFBI, PCDHA10, PCDHA11, PCDHA12, PCDHA13, NEGR1, FN1, COL15A1, CERCAM, COL4A6, AMIGO2, ITGA6, ITGA5, CYFIP2
Extracellular matrix	4.58	COL4A2, LTBP1, COL4A1, LTBP2, TNC, NTN4, COL15A1, OLFML2A, COL5A3, ECM1, COL5A1, COL4A6, CPZ, TIMP1, CTGF, TGFBI, THSD4, COL1A1, TFPI2, FN1
Cell motion and migration	3.78	TNFRSF12A, PLXNA2, TGFBR1, ITGA11, CDH2, CERCAM, COL5A1, PLAUR, EPHB2, CD97, ITGA6, ITGA5, CTGF, SERPINB5, DNER, SEMA3A, ETV4, DCLK1, RUNX3, FN1
Growth factor binding	3.41	FGFBP3, LTBP1, COL4A1, LTBP2, CTGF, HTRA1, IGFBP7, TGFBR1, COL1A1, COL5A1, CRIM1
Cell differentiation	2.62	NOTCH3, SMAD7, TGFBR1, RCAN1, ABCA1, SEMA3A, JAG1, ABCG1, KLF4, EPHB2, MBP, THY1
EGF/Notch signaling	2.34	NOTCH3, CD97, LTBP1, LTBP2, TNC, DNER, PTGS1, JAG1, ADAM19, MAML3, FOXC2
Integrin binding	2.06	ITGA6, CTGF, ITGA5, TGFBI, COL5A1, THY1

Down Cluster Representative Term	Enrichment Score	Representative Genes
Aldo/keto reductase and NADP	2.92	AKR1C3, AKR1C2, AKR1C4, KCNAB2, FASN, AKR1C1, FDFT1
GPI-anchor	2.52	CPM, ALPPL2, FOLR1, NTNG1, PSCA, ALPP
Steroid metabolic process	2.34	SOAT1, AKR1C2, AKR1C4, SQLE, HMGCS1, LSS, IDI1, AKR1C1, SREBF2, FDFT1
Lipid and fatty acid synthesis	1.76	ELOVL2, HMGCS1, FASN, FADS2, LSS, IDI1, FDFT1