TABLE 2.
Post-transplant Outcomes
| Pre-transplant | Post-transplant | p Value | |
|---|---|---|---|
| LVEF | |||
|
| |||
| All subjects | 53 ± 10 | 56 ± 10 | 0.002 |
| Baseline LVSD (n = 66)* | 41 ± 10 | 50 ± 12 | <0.0001 |
| Baseline moderate LVSD* (n = 28) | 32 ± 7 | 47 ± 14 | <0.0001 |
|
| |||
| LVM/BSA, g/m2 | |||
|
| |||
| All subjects | 132 ± 46 | 125 ± 42 | 0.032 |
| Baseline LVH* (n = 151) | 154 ± 40 | 134 ± 45 | <0.0001 |
| Baseline severe LVH* (n = 90) | 176 ± 36 | 138 ± 42 | <0.0001 |
|
| |||
| LVDd, cm | |||
|
| |||
| All subjects | 4.8 ± 0.7 | 4.7 ± 0.7 | 0.005 |
| Baseline ≥5.6 (n = 33) | 6.0 ± 0.4 | 5.0 ± 0.8 | <0.0001 |
|
| |||
| IVS diameter, cm | |||
|
| |||
| All subjects | 1.4 ± 0.3 | 1.4 ± 0.3 | 0.984 |
| Baseline ≥1.2 (n = 180) | 1.5 ± 0.2 | 1.4 ± 0.3 | <0.001 |
|
| |||
| PW diameter, cm | |||
|
| |||
| All subjects | 1.2 ± 0.3 | 1.2 ± 0.3 | 0.974 |
| Baseline ≥1.2 (n = 140) | 1.4 ± 0.2 | 1.3 ± 0.3 | <0.0001 |
|
| |||
| RVSP, mm Hg | |||
|
| |||
| All subjects | 35 ± 11 | 34 ± 12 | 0.728 |
| Baseline ≥40 (n = 35) | 48 ± 8 | 38 ± 15 | <0.001 |
|
| |||
| Diastolic dysfunction | |||
|
| |||
| Stage 2 | 56 (24) | 50 (22) | |
| Stage 3 | 7 (3) | 6 (3) | |
|
| |||
| Blood pressure, mm Hg | |||
|
| |||
| All subjects SBP | 136 ± 25 | 132 ± 22 | 0.026 |
| All subjects DBP | 76 ± 13 | 74 ± 13 | 0.080 |
| Baseline SBP ≥130 (n = 130) | 152 ± 19 | 134 ± 22 | <0.0001 |
| Baseline SBP ≥140 (n = 95) | 159 ± 18 | 137 ± 23 | <0.0001 |
| Baseline DBP ≥80 (n = 86) | 88 ± 10 | 78 ± 14 | <0.0001 |
| Baseline DBP ≥90 (n = 28) | 99 ± 11 | 81 ± 13 | <0.0001 |
|
| |||
| Hemoglobin, g/dl | |||
|
| |||
| All subjects | 11.8 ± 1.5 | 12.3 ± 2.0 | <0.001 |
| Baseline anemia† (n = 165) | 11.1 ± 1.1 | 12.2 ± 2.1 | <0.0001 |
|
| |||
| Medications | |||
|
| |||
| Beta-blocker | 141 (61) | 148 (64) | 0.733 |
| ACE inhibitor or ARB | 67 (29) | 37 (16) | <0.001 |
| Aldosterone antagonist | 0 (0) | 3 (1) | 0.083 |
| Hydralazine | 24 (10) | 19 (8) | 0.354 |
| Nitrate | 21 (9) | 17 (7) | 0.347 |
|
| |||
| Mortality | |||
|
| |||
| 1 year | 15 (7) | ||
| 3 years | 25 (11) | ||
| 5 years | 33 (14) | ||
Values are mean ± SD or n (%).
*
Reference values defined by American Society of Echocardiography guidelines (6).
†
Defined as hemoglobin <13 g/dl in males and <12 g/dl in females (9).
ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; DBP = diastolic blood pressure; IVS = interventricular septum; LVDd = left ventricular end-diastolic dimension; LVH = left ventricular hypertrophy; LVM/BSA = left ventricular mass indexed to body surface area; LVSD = left ventricular systolic dysfunction; PW = posterior wall; RVSP = right ventricular systolic pressure; SBP = systolic blood pressure; other abbreviations as in Table 1.