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. 2015 Sep 18;12(9):1054–1066. doi: 10.1080/15476286.2015.1079682

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Wen-Chi Lee, Shin-Hua Lu, Ming-Hsuan Lu, Chen-Jui Yang, Shu-Hsing Wu, and Ho-Ming Chen

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — An atypical duplex region or overhang characterizes 20-nt miRNA duplexes. (A) Flowchart for the identification of 20-nt miRNA duplexes. The detailed procedures are described in the Materials and Methods. (B) Structure of a canonical 21-nt duplex. The length of the duplex region and the overhang is indicated in base pairs (bp) and nucleotides (nt), respectively in (B) and (C). The duplex region is highlighted in yellow and the nucleotides in asymmetric bulges are not plotted and contribute to the length of the duplex region in (B) and (C). (C) Three groups of 20-nt miRNA duplexes. The 20-nt miRNA strand and the complementary strand are highlighted in red and turquoise, respectively. The nucleotides presumed missing are indicated in gray. miRNA families assigned to each group are listed.