Table 1.
Cohort characteristics (mean / SD or n / %) by annual assessment cycle
| Cycle 1 | Cycle 2 | Cycle 3 | Cycle 4 | Cycle 5 | |
|---|---|---|---|---|---|
| N | 1980 | 1697 | 1467 | 1320 | 1161 |
| Age, mean (SD) | 77.65 (7.44) | 78.47 (7.34) | 79.16 (7.20) | 79.90 (7.15) | 80.51 (7.07) |
| % female | 61.05 | 62.05 | 62.99 | 63.26 | 63.05 |
| % ≥ HS education | 86.23 | 86.74 | 87.71 | 87.42 | 87.42 |
| % white | 94.70 | 94.87 | 94.72 | 95.15 | 95.09 |
| CDR | |||||
| % 0 | 71.29 | 73.72 | 72.14 | 71.89 | 73.56 |
| % 0.5 | 27.55 | 24.99 | 25.85 | 25.68 | 23.77 |
| % > = 1 | 1.16 | 1.30 | 2.0 | 2.42 | 2.67 |
| % APOE*4 allele | 20.92 | 21.23 | 21.36 | 21.03 | 21.17 |
| Subjective health | |||||
| % Poor/Fair | 17.44 | 15.26 | 14.91 | 14.24 | 16.62 |
| % Good | 45.70 | 47.26 | 48.93 | 50.53 | 46.94 |
| % Very Good/Excellent | 36.86 | 37.48 | 36.16 | 35.23 | 36.43 |
| Number Rx meds | |||||
| % 0 | 8.8 | 8.37 | 7.35 | 7.12 | 6.46 |
| % 1–3 | 35.76 | 34.20 | 35.20 | 33.18 | 33.07 |
| % >= 4 | 55.44 | 57.43 | 57.45 | 59.70 | 60.47 |
| MMSE, mean (SD) | 26.94 (2.43) | 27.04 (2.72) | 27.03 (2.68) | 27.0 (3.03) | 26.94 (3.17) |
| mCESD score (SD) | 0.94 (2.08) | 0.72 (1.92) | 0.67 (1.87) | 0.52 (1.49) | 0.48 (1.55) |
| Objective Memory | |||||
| WMS-R Logical Memory IR, mean (SD) | 19.67 (7.27) | 20.49 (7.38) | 21.36 (7.46) | 21.89 (7.67) | 22.52 (7.84) |
| WMS-R Visual Reproduction IR, mean (SD) | 27.56 (7.19) | 28.37 (7.02) | 28.08 (7.09) | 27.84 (7.27) | 28.10 (7.16) |
| Fuld OME, mean (SD) | 21.86 (4.30) | 22.92 (4.75) | 23.33 (4.85) | 23.36 (5.14) | 23.46 (5.20) |
| Objective Language | |||||
| Semantic fluency, mean (SD) | 15.57 (4.83) | 15.63 (4.89) | 15.60 (5.02) | 15.62 (4.99) | 15.55 (4.81) |
| IU Token Test, mean (SD) | 22.67 (1.80) | 22.72 (1.84) | 22.75 (1.88) | 22.79 (1.86) | 22.83 (1.88) |
| BNT, mean (SD) | 52.96 (6.04) | 53.15 (6.11) | 53.26 (6.33) | 53.19 (6.30) | 53.17 (6.66) |
| Objective Executive Functions | 22.67 (1.80) | 22.72 (1.84) | 22.75 (1.88) | 22.79 (1.86) | 22.83 (1.88) |
| Trail Making B, (connections / s) mean (SD) | 0.2372 (0.1011) | 0.2440 (0.1129) | 0.2567 (0.1114) | 0.2553 (0.1100) | 0.2539 (0.1127) |
| Phonemic fluency (FAS), mean (SD) | 11.97 (4.46) | 12.09 (4.62) | 12.31 (4.38) | 12.52 (4.54) | 12.83 (4.52) |
| Clock drawing | 13.50 (1.79) | 13.52 (1.87) | 13.56 (1.81) | 13.66 (1.87) | 13.69 (1.85) |
| Subjective memory symptoms, mean (SD) (range 0 – 16) | 2.08 (2.30) | 1.80 (2.27) | 1.89 (2.31 | 2.0 (2.41) | 2.0 (2.48) |
Note. CDR = Clinical Dementia Rating scale; MMSE = Mini Mental State Exam; WMS-R = Wechsler Memory Scale – Revised; OME = Object Memory Evaluation; IU = Indiana University; BNT = Boston Naming Test. APOE*4 = Apolipoprotein E gene, presence of at least one E*4 allele; mCESD = modified Center for Epidemiologic Studies Depression scale.