Table 1. Baseline characteristics of the study population.
| Total(N = 567)(100%) | NormalizedN = 62(10.9%) | Non NormalizedN = 505(89.1%) | |
|---|---|---|---|
| Age (year), mean ± sd | 42.5±10.3 | 40.4±11.4 | 42.7±10.1 |
| Gender | |||
| Male | 385 | 39 (10.1%) | 346 (89.9%) |
| Female | 182 | 23 (12.6%) | 159 (87.4%) |
| BMI | |||
| (kg/m2 )*, mean ± sd | 22.7±4.1 | 22.2±3.4 | 22.8±4.2 |
| HCV coinfection | |||
| No | 424 | 47 (11.1%) | 377 (88.9%) |
| Yes | 143 | 15 (10.5%) | 128 (89.5%) |
| AIDS-defining condition | |||
| No | 426 | 55 (12.9%) | 371 (88.9%) |
| Yes | 141 | 7 (5.0%) | 134 (95.0%) |
| Mode of contamination | |||
| Heterosexual | 251 | 34 (13.6%) | 217 (86.4%) |
| Homo-bisexual | 179 | 18 (10.1%) | 161 (89.9%) |
| IV drug user | 87 | 5 (5.7%) | 82 (94.3%) |
| Other | 50 | 6 (12.0%) | 44 (88.0%) |
| Calendar year | |||
| Early cART, ≤ 2005 | 134 | 14(10.4%) | 120 (89.6%) |
| Late cART, > 2005 | 433 | 48(11.1%) | 385 (88.9%) |
| Diagnosis-to-treatment delay (years)(mean±SD) | 8.1±7.4 | 6.1±7.5 | 8.3±7.4 |
| Baseline CD4 count (cells/mm3)(median [IQR]) | 304[171;476] | 460[313;621] | 286[155;462] |
| Nadir CD4 (cells/mm3)(median [IQR]) | 277[151;427] | 416[308;571] | 260[138;405] |
| Baseline CD8 count (cells/mm3)(median [IQR]) | 863[602;1202] | 758[480;1003] | 876[610;1242] |
| Baseline ratio (median [IQR]) | 0.36[0.19;0.56] | 0.74[0.44;0.84] | 0.32[0.18;0.50] |
| Viral load (log10)* (median [IQR]) | 3.26[1.60;4.75] | 3.26[1.60;5.00] | 3.26[1.60;4.72] |
| Dyslipidemia* | |||
| No | 122 | 21 (17.2%) | 101 (82.8%) |
| Yes | 67 | 3 (4.5%) | 64 (95.5%) |
| Missing | 378 | 38 (10.0%) | 340 (90.0%) |
| cART treatment | |||
| PI-based regimens | 300 | 36 (12.0%) | 264 (88.0%) |
| NNRTI-based regimens | 168 | 17(10.1%) | 151 (89.9%) |
| NRTI-based regimens (≥3 NRTI) | 59 | 3 (5.1%) | 56 (94.9%) |
| Other (incl PI + NNRTI) | 40 | 6 (15.0%) | 34 (85.0%) |
| INSTI-containing regimens | |||
| No | 522 | 52 (10.0%) | 470 (90.0%) |
| Yes | 45 | 10 (22.2%) | 35 (77.8%) |
| incl. | |||
| PI-based association | 11 | 4 (36.4%) | 7 (63.6%) |
| NNRTI-based association | 3 | 0 (0.0%) | 3 (100.0%) |
| NRTI-based association (2 NRTI) | 25 | 6 (24.0%) | 19 (76.0%) |
| Other (incl PI + NNRTI) | 6 | 0 (0.0%) | 6 (100.0%) |
Abbreviations—cART, combined antiretroviral therapy; sd, standard deviation; IQR, interquartile range. incl, including.