Table 1. Comparison of mean intraocular pressure (mmHg) at baseline and after treatment with bimatoprost 0.01% once at night and after timolol 0.5% bid.

Measurement	Baseline	Timolol 0.5% bid	Mean difference from baseline	p value	Bimatoprost 0.01% plus placebo	Mean difference from baseline	p value	Mean difference between treatments	p value
	Mean (95% CI)	Mean (95% CI)	Mean (95% CI)	-	Mean (95% CI)	Mean (95% CI)	-	Mean (95% CI)	-
Mean 24h IOP	20.3 (19.0 to 21.6)	16.8 (15.8 to 17.8)	-3.5 (-2.6 to -4.4)	<0.0001	15.7 (14.8 to 16.7)	-4.5 (-3.6 to -5.4)	<0.0001	-1.0 (-0.3 to -1.7)	0.0003
Mean Day IOP	20.9 (19.6 to 22.3)	16.5 (15.5 to 17.5)	-4.4 (-3.5 to -5.3)	<0.0001	15.5 (14.6 to 16.4)	-5.4 (-4.4 to -6.4)	<0.0001	-1.0 (-0.3 to -1.6)	0.0007
Mean Night IOP	18.6 (17.2 to 20.0)	17.5 (16.1 to 18.8)	-1.1 (0.0 to -2.3)	0.056	16.3 (15.2 to 17.5)	-2.3 (-1.2 to -3.4)	0.0002	-1.1 (-0.2 to 2.1)	0.0019
8:00	22.5 (20.6 to 24.4)	17.5 (16.3 to 18.6)	-5.0 (-3.2 to -6.8)	<0.0001	15.9 (14.9 to 16.9)	-6.6 (-4.8 to -8.3)	<0.0001	-1.5 (-0.5 to -2.5)	0.0014
12:00	20.8 (19.0 to 22.2)	16.2 (15.1 to 17.4)	-4.5 (-3.2 to -5.9)	<0.0001	15.4 (14.3 to 16.5)	-5.4 (-4.1 to -6.8)	<0.0001	-0.9 (-0.1 to -1.7)	0.045
16:00	21.1 (19.5 to 22.8)	16.1 (14.9 to 17.4)	-5.0 (-3.9 to -6.1)	<0.0001	14.9 (13.8 to 15.9)	-6.3 (-4.8 to -7.7)	<0.0001	-1.3 (-0.2 to -2.4)	0.03
20:00	19.3 (18.0 to 20.5)	16.0 (14.8 to 17.2)	-3.3 (-2.1 to -4.5)	<0.0001	15.6 (14.4 to 16.8)	-3.7 (-2.4 to -4.9)	<0.0001	-0.4 (-0.7 to -1.6)	0.56
00:00	18.2 (16.8 to 19.5)	17.3 (15.9 to 18.7)	-0.9 (+0.6 to -2.1)	0.23	16.1 (14.9 to 17.4)	-2 (-0.65 to -3.4)	0.0034	-1.2 (-0.2 to -2.1)	0.0069
04:00	19.1 (17.3 to 20.8)	17.6 (16.2 to 19.1)	-1.4 (0.0 to -2.8)	0.092	16.6 (15.3 to 17.8)	-2.5 (-1.0 to -4.0)	0.0014	-1.0 (0.0 to -2.2)	0.012

IOP = Intraocular pressure; CI = confidence interval; bid = bis in die. Mean day IOP = mean of 08:00, 1200, 16:00 and 20:00 o’clock timeponts; Mean night IOP = mean of 00:00 and 04:00 o’clock timepoints.