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. 2015 Feb 12;6(2):93–101. doi: 10.1080/19491034.2015.1004941

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Jana Link, Daniel Jahn, and Manfred Alsheimer

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Mammalian meiotic and somatic LINC complexes. The SUN-domain proteins SUN1 and/or SUN2 are central INM components of mammalian LINC complexes, both in meiotic and somatic cells. The meiotic LINC complex further consists of the ONM residing meiosis-specific KASH5 protein, which via dynein/dynactin likely connects to the microtubule cytoskeleton. In somatic cells, versatile, cell-type specific KASH-domain proteins interact with SUN1 and/or 2 to form several distinct LINC complexes. The different KASH proteins in turn specifically connect to different components of the cytoskeleton, allowing the LINC complexes to fulfill specialized cellular functions.