Figure 2.

Freeze fracture showing intercellular junctions in wild-type and Claudin 11-null mice. a, Parallel intramembranous fibrils of claudin 11 TJs (white arrowheads) separate small gap junction domains (black arrowheads) in wild-type P 90 mice. b, Tight junction strands are absent in P90 Claudin 11-null mice, and gap junctions form large domains with defined borders. c, Tight and gap junctions are well developed in P30 wild-type mice and are similar to adults. d, Tight junction domains are absent in null mutant mice but gap junctions are present. Scale bar, 0.15 μm.