Figure 7.

Freeze fracture showing normal marginal cell TJs and basolateral infoldings in Claudin 11-null mice. A, Claudin 1 TJ strands (arrowheads) in marginal cells from wild-type (a, c) and null mutant (b, d) mice at P90 (a, b) and P30 (c, d). Scale bar, 100 nm. B, Basolateral infoldings in marginal cells from wild-type (a, c) and null mutant (b, d) mice at P90 (a, b) and P30 (c, d). Characteristic packing of intramembranous particles reflects the presence of Na⁺/K⁺ ATPases and other integral proteins (star). Asterisk in d marks atypical morphology that may be a sign of localized edema in the stria vascularis of an adult mutant. Scale bar, 100 nm.